Cells

Crown Scientific cells are the only human cells tested for Purity and Immune Potency!

Our patent-pending potency test includes human immune-regulation of both adaptive and innate immune system

 

Primary cells are identified for purity of MSC based on ISCT standards:

- Plastic Adherence (spindle morphology)

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Immunophenotyping:

- Positive (>90%): CD105, CD90, CD73, CD29, CD44

- Negative (<10%): CD45, CD34, CD19, CD14, CD11b, CD79a, HLD-DR

 

Antibody 

Population (%)

CD105

+++

CD73

+++

CD90

+++

CD29

+++

CD44

+++

CD45

-

CD34

-

CD14

-

CD79a

-

CD11b

-

HLADR

-

 

 

- Tri-lineage differentiation*: Adipocyte, Chondrocyte, Osteocyte 

 

adipo.pngchondro.pngosteo.png

 

 

Our cells are tested for Immune regulation potency (Anti-inflammatory effect): Potency assays are performed in order to evaluate and make sure that the potency to cause immune-supression is adequate in every released batch. The immune system can be divided in two: the adaptive (acquired immunity) and innate (first  line of defense), at Crown Scientific we test the potency of our MSCs to regulate both immune systems:

 

- Adaptive Immune System inhibition (IC50): 

adaptive2.png

 

- Innate Immune System inhibition (IC50)

innate1.png 

 

Carry on your research with reliable Crown Scientific potency and identity tested cells.

 

 

* not all perinatal MSCs are capable of mature tri-lineage differentiation.