Crown Scientific cells are the only human cells tested for Purity and Immune Potency!
Our patent-pending potency test includes human immune-regulation of both adaptive and innate immune system
Primary cells are identified for purity of MSC based on ISCT standards:
- Plastic Adherence (spindle morphology)
Immunophenotyping:
- Positive (>90%): CD105, CD90, CD73, CD29, CD44
- Negative (<10%): CD45, CD34, CD19, CD14, CD11b, CD79a, HLD-DR
|
Antibody |
Population (%) |
|
CD105 |
+++ |
|
CD73 |
+++ |
|
CD90 |
+++ |
|
CD29 |
+++ |
|
CD44 |
+++ |
|
CD45 |
- |
|
CD34 |
- |
|
CD14 |
- |
|
CD79a |
- |
|
CD11b |
- |
|
HLADR |
- |
- Tri-lineage differentiation*: Adipocyte, Chondrocyte, Osteocyte
Our cells are tested for Immune regulation potency (Anti-inflammatory effect): Potency assays are performed in order to evaluate and make sure that the potency to cause immune-supression is adequate in every released batch. The immune system can be divided in two: the adaptive (acquired immunity) and innate (first line of defense), at Crown Scientific we test the potency of our MSCs to regulate both immune systems:
- Adaptive Immune System inhibition (IC50):
- Innate Immune System inhibition (IC50)
Carry on your research with reliable Crown Scientific potency and identity tested cells.
* not all perinatal MSCs are capable of mature tri-lineage differentiation.